Technology

Accelerating and scaling immune cell engineering

Effective application of innovative technology in biological research requires a collaborative and cross-disciplinary mindset.

We are a diverse group of engineers, scientists, and synthetic biologists dedicated to empowering our Discovery and Development organizations through design and deployment of state-of-the-art computational and biological tools.

Senior Research Associate, Synthetic Biology

ArsenalBio’s mission is to develop efficacious and safe cellular therapies for patients with chronic diseases, initially cancer.  Our products are being designed to herald the transition of adoptive cell therapy from a hospital based treatment to outpatient therapy, like most other cancer treatments. 

Our people are our greatest asset, they bring scientific talents in molecular biology, immunology, pharmacology, protein chemistry, computational biology, automation, genome engineering, software and other fields to make the future happen now.

Our approach requires novel receptors to empower cell therapies to sense their environment and respond as needed to resolve disease states. This role in ArsenalBio’s Synthetic Biology group lies on the forefront of development and application of those novel synthetic receptors. In it, you will interface closely with colleagues across ArsenalBio, as well as external collaborators and thought leaders.

What You Will Do

  • Design and execute experiments with the aim to develop and optimize synthetic immune receptors and related proteins for cell therapy applications
  • Develop and apply methods for pooled and arrayed high-throughput functional screening of large protein libraries in primary immune cells and cell lines
  • Develop DNA constructs and libraries encoding immune receptor domains, variants and fusions from rational, semi-rational and randomized designs
  • Collect, analyze and interpret experimental data, keeping detailed accounts of experiments for regular group and company wide data presentations
  • Work with interdisciplinary teams to establish and test novel cell therapy approaches
  • Maintain familiarity with the relevant current literature and its application to protein engineering, synthetic immunology and cell therapy
  • Coordinate tasks across multiple projects, demonstrating prioritization and planning
  • Interpret and effectively execute experiments in line with project timelines and goals
  • What You Will Bring

  • BA/BS or MA/MS in molecular biology, immunology, protein engineering or a related field, with 0-2+ years of relevant research experience in industry or academia (Required)
  • Proficiency in molecular biology laboratory techniques, cell culture, and flow cytometry

  • Preferred:
  • Experience with high-throughput functional characterization of DNA and protein libraries in pooled and/or arrayed formats 
  • Working knowledge of NGS technologies and workflows 
  • Experience optimizing/developing protocols for DNA assembly and library construction for synthetic biology and protein engineering
  • Entrepreneurial behaviors demonstrated by agility, accountability, transparency, resourcefulness, and ability to get things done
  • Ability to quickly learn new skills and knowledge on the job, demonstrate productivity, and deliver high-quality results 
  • Flexible mind with ability to think outside the box, creative approach to problem solving, and comfort in working with ambiguous data in an open-ended, exploratory process
  • Demonstrated ability to perform as a team player

  • Pluses:
  • Familiarity with R or similar environments for pipelining of routine data analysis
  • Collaborative experience with computational biologists and/or software engineers to help develop and use novel tools for construct design, experimental planning and/or data analysis
  • Experience with multiplexing/barcoding approaches for scaling experimental throughput
  • We are committed to hiring the best talent. A diverse workforce engenders richness of thought, creativity and discovery. We invite individuals who embrace intellectual achievement to bring their unique personal and professional journeys and together we will build transformative cell therapies for cancer patients.

    We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

    To all recruitment agencies: ArsenalBio does not accept agency resumes. Please do not forward resumes to our jobs alias, or Arsenalbio employees. ArsenalBio is not responsible for any fees related to unsolicited resumes.



    Apply     

    “Modern data science, automation, and synthetic biology approaches have tremendous potential to accelerate the development of effective cell therapies. ArsenalBio is being built from the ground up to optimize the leveraging of these approaches through early and deep integration of engineers and technologists into our R&D programs. We are seeking ambitious and talented teammates to join us in our mission to improve the lives of cancer patients.”


    Tarjei Mikkelsen, PhD

    Chief Technology Officer

    Benefits

    Best in Class Health & Wellness Plans

    Flexible Office Hours

    Paid Parental Leave

    Healthy Kitchen Snacks

    Daily Catered Lunches

    Free Onsite Fitness Center

    Unlimited Vacation Days

    Generous compensation and equity packages

    Commuter Benefits

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