ArsenalBio’s mission is to develop efficacious and safe cellular therapies for patients with chronic diseases, initially cancer. Our products are being designed to herald the transition of adoptive cell therapy from a hospital based treatment to outpatient therapy, like most other cancer treatments. Our people are our greatest asset, they bring scientific talents in molecular biology, immunology, pharmacology, protein chemistry, computational biology, automation, genome engineering, software and other fields to make the future happen now.
Our approach requires novel receptors to empower cell therapies to sense their environment and respond as needed to resolve disease states. This role in ArsenalBio’s Synthetic Biology group lies on the forefront of development and application of those novel synthetic receptors. In it, you will interface closely with colleagues across ArsenalBio’s Research, Development and Technology organizations, as well as external collaborators and thought leaders.
What You Will DoLead the high-throughput and high-content screening of synthetic immune receptors for a portfolio of cell therapy applicationsDevelop and apply methods for pooled and arrayed high-throughput functional screening of large protein libraries in primary immune cells and cell linesDevelop DNA constructs and libraries encoding immune receptor domains, variants and fusions from rational, semi-rational and randomized designsDissect and model the biochemical and functional characteristics of select receptor designsWork with interdisciplinary teams to establish and test novel cell therapy approachesProvide expert support for multiplexing and scaling biological readouts across our broader scientific teamMaintain familiarity with the relevant current literature and its application to multiplexing readouts, synthetic immunology and cell therapyCoordinate tasks across multiple projects, demonstrating prioritization and planningInterpret and effectively execute experiments in line with project timelines and goalsRecruit and mentor junior scientists and research associates with relevant expertise
What You Will BringPhD in molecular biology, immunology, protein engineering or a related field, with 3+ years of relevant research experience in industry or academiaExperience with functional screening of engineered immune cellsExperience with high-throughput functional characterization of DNA and protein libraries in pooled and/or arrayed formatsExperience in developing flow cytometry protocols for synthetic biology applicationsWorking knowledge of NGS technologies and workflowsEntrepreneurial behaviors demonstrated by agility, accountability, transparency, resourcefulness, and ability to get things doneAbility to quickly learn new skills and knowledge on the job, demonstrate productivity, and deliver high-quality results Flexible mind with ability to think outside the box, creative approach to problem solving, and comfort in working with ambiguous data in an open-ended, exploratory processDemonstrated ability to perform as a team player
What We Hope You Might BringFamiliarity with R or similar environments for pipelining of routine data analysisCollaborative experience with computational biologists and/or software engineers to help develop and use novel tools for construct design, experimental planning and/or data analysisExperience with multiplexing/barcoding approaches for scaling experimental throughput
We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status
To all recruitment agencies: ArsenalBio does not accept agency resumes. Please do not forward resumes to our jobs alias, or Arsenalbio employees. ArsenalBio is not responsible for any fees related to unsolicited resumes.