Technology

Accelerating and scaling immune cell engineering

Effective application of innovative technology in biological research requires a collaborative and cross-disciplinary mindset.

We are a diverse group of engineers, scientists, and synthetic biologists dedicated to empowering our Discovery and Development organizations through design and deployment of state-of-the-art computational and biological tools.

Accelerating and scaling immune cell engineering

Effective application of innovative technology in biological research requires a collaborative and cross-disciplinary mindset.

Senior Scientist - NGS

ArsenalBio’s mission is to develop efficacious and safe cellular therapies for patients with chronic diseases, initially cancer. Our products are being designed to herald the transition of adoptive cell therapy from a hospital based treatment to outpatient therapy, like most other cancer treatments.

Our people are our greatest asset, they bring scientific talents in molecular biology, immunology, pharmacology, protein chemistry, computational biology, automation, genome engineering, software and other fields to make the future happen now.

We are seeking an outstanding scientist to drive next-generation sequencing methods within ArsenalBio. The ideal candidate will have a broad understanding of NGS and its applications and a proven track record of developing innovative NGS protocols for solving complex biological problems. As a strong technical contributor, this role will collaborate with internal and external stakeholders to advance ArsenalBio research.

What You Will Do

Deploy high- and low-throughput NGS library preparation strategies for bulk, single-cell, and multi-omic applications

Create NGS libraries from single cells, tissues, and isolated DNA/RNA to further ArsenalBio research and discovery

Establish novel NGS methods to extract new types of information from research and clinical samples

Help oversee the operation and maintenance of numerous Illumina instruments

Participate in the overall management of NGS operations

Assist in troubleshooting problematic library preps and sequencing issues

Contribute to ongoing improvements in storing, tracking, and analyzing NGS data

Evaluate new NGS technologies and platforms (e.g. spatial transcriptomics)

Identify promising new concepts in scientific publications and lead pilot studies of related experiments

Participate in cross-functional collaborations with multiple groups to advance broad company goals and objectives and assist in the design of genomics projects

Contribute NGS expertise, leadership, and technical guidance to cross-disciplinary teams.

Advance NGS technology utilization and understanding across the company

Work closely with computational biologists to interpret NGS data

What You Will Bring

Ph.D. (preferred) or Masters in Genetics, Biology, Biochemistry, Chemistry or a closely-related field

3+ years of full-time, hands-on NGS experience in an academic or industrial setting

Deep understanding of NGS library preparation and the principles of sequencing technologies

Previous work with a variety of NGS sample preparation workflows and analysis

Experience in high-content screening, single-cell genomics, or functional genomics

Significant experience in troubleshooting, method development, and optimization of molecular biology-based assays

Strong background in molecular biology and analytical techniques including, PCR/qPCR, ddPCR, molecular cloning, gene editing, enzymatic assays, and nucleic acid isolation and manipulation

Experience operating liquid handling robots or other lab automation for high-throughput assays is desired

Experience in computational analysis of next-generation sequencing data

Managerial experience and/or project management experience

Ability to quickly learn new skills and knowledge on the job, demonstrate productivity and deliver high-quality results

We are committed to hiring the best talent. A diverse workforce engenders richness of thought, creativity and discovery. We invite individuals who embrace intellectual achievement to bring their unique personal and professional journeys and together we will build transformative cell therapies for cancer patients.

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

To all recruitment agencies: ArsenalBio does not accept agency resumes. Please do not forward resumes to our jobs alias, or Arsenalbio employees. ArsenalBio is not responsible for any fees related to unsolicited resumes.

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“Modern data science, automation, and synthetic biology approaches have tremendous potential to accelerate the development of effective cell therapies. ArsenalBio is being built from the ground up to optimize the leveraging of these approaches through early and deep integration of engineers and technologists into our R&D programs. We are seeking ambitious and talented teammates to join us in our mission to improve the lives of cancer patients.”

Tarjei Mikkelsen, PhD

Chief Technology Officer