Technology

Accelerating and scaling immune cell engineering

Effective application of innovative technology in biological research requires a collaborative and cross-disciplinary mindset.

We are a diverse group of engineers, scientists, and synthetic biologists dedicated to empowering our Discovery and Development organizations through design and deployment of state-of-the-art computational and biological tools.

Director, Cell Engineering

ArsenalBio’s mission is to develop efficacious and safe cellular therapies for patients with chronic diseases, initially cancer.  Our products are being designed to herald the transition of adoptive cell therapy from a hospital based treatment to outpatient therapy, like most other cancer treatments.  Our people are our greatest asset, they bring scientific talents in molecular biology, immunology, pharmacology, protein chemistry, computational biology, automation, genome engineering, software and other fields to make the future happen now.

This role will lead development of novel technologies for cell programming, manipulation and
screening, and drive dissemination and application of these technologies across all ArsenalBio
discovery and development programs.

What You Will Do:

  • Lead and mentor a team of scientists and research associates dedicated to development and application of a state-of-the-art cell engineering technology platform
  • Develop technologies for precise, efficient genome engineering in complex cell populations, including primary immune cells and disease models
  • Develop genome engineering and synthetic biology approaches for robust, predictable programming of immune cell behavior and states
  • Develop approaches for high-throughput/multiplexed functional and phenotypic screening of engineered cells in vitro and in vivo
  • Collaborate with automation engineers, software engineers and operations specialists to scale and optimize the operation of the cell engineering platform
  • Collaborate with cross-disciplinary teams to apply the cell engineering platform to discover, develop and validate effective therapeutic products
  • Collaborate with executive and business development teams to develop publication, commercialization and partnering strategies
  • Communicate technical capabilities and advances in industry meetings, scientific presentations and publications
  • Coordinate tasks across multiple projects, demonstrating prioritization and planning
  • Interpret and effectively execute interdependent tasks in line with project timelines and goals

  • What You Will Bring

  • PhD in cell, molecular, immunological, or genomic basis of human diseases, with 15+ years of relevant research experience in industry or academia
  • Experience developing methods for genome engineering in primary immune cells
  • Experience developing methods for high-throughput functional genomics and/or genetic screening in complex cell populations
  • Experience developing synthetic circuits and/or genetic components for rational control of cellular behaviors and states
  • Working knowledge of viral and non-viral vector delivery methods
  • Working knowledge of high-throughput DNA sequencing and synthesis
  • Working knowledge of advanced molecular assays, including single-cell sequencing
  • Entrepreneurial behaviors demonstrated by agility, accountability, transparency, resourcefulness, and ability to get things done
  • Ability to quickly learn new skills and knowledge on the job, demonstrate productivity, and deliver high-quality results
  • Flexible mind with ability to think outside the box, creative approach to problem solving, and comfort in working with ambiguous data in an open-ended, exploratory process
  • Demonstrated ability to perform as a team player
  • We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status

    To all recruitment agencies: ArsenalBio does not accept agency resumes. Please do not forward resumes to our jobs alias, or Arsenalbio employees. ArsenalBio is not responsible for any fees related to unsolicited resumes.

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    “Modern data science, automation, and synthetic biology approaches have tremendous potential to accelerate the development of effective cell therapies. ArsenalBio is being built from the ground up to optimize the leveraging of these approaches through early and deep integration of engineers and technologists into our R&D programs. We are seeking ambitious and talented teammates to join us in our mission to improve the lives of cancer patients.”


    Tarjei Mikkelsen, PhD

    Chief Technology Officer

    Benefits

    Best in Class Health & Wellness Plans

    Flexible Office Hours

    Paid Parental Leave

    Healthy Kitchen Snacks

    Daily Catered Lunches

    Free Onsite Fitness Center

    Unlimited Vacation Days

    Generous compensation and equity packages

    Commuter Benefits