Medical Sciences

Senior Director, Translational Biometrics

ArsenalBio’s mission is to develop efficacious and safe cellular therapies for patients with chronic diseases, initially cancer.  Our products are being designed to herald the transition of adoptive cell therapy from a hospital based treatment to outpatient therapy, like most other cancer treatments. 

Our people are our greatest asset, they bring scientific talents in molecular biology, immunology, pharmacology, protein chemistry, computational biology, automation, genome engineering, software and other fields to make the future happen now.

Translational science facilitates the rapid application of advances in science with better medicine. Senior director of Translational Biometrics will lead the analytical planning for clinical biomarker and translational research plans. This role will report to the Head of Medical Sciences and will work within a matrix team to enable productive interactions across research functions. This role will require an ability to operate in a fast-paced, highly dynamic environment with partnerships that include both internal and external stakeholders.

What You Will Do:

  • Deliver statistical analyses plan to assess exploratory hypotheses in Translational Science: To support dose selection (PK/PD); To demonstrate proof of mechanism: To define novel mechanisms of resistance.
  • Collaborate with Computational Biology to create models and integrate datasets pulled from NGS, proteomics and other sources, in order to evaluate hypotheses and provide direction for translational science projects.
  • Collaborate with the technology team to develop an integrated approach to data management including clinical data.
  • Collaborate with preclinical and clinical development teams to create sample management plans.
  • Lead the implementation of biometric plans to enable target validation, early indication of biological activity and patient stratification/selection in early phase clinical trials.
  • Collaborate across research functions to incorporate Translational Science strategies and implement exploratory analyses.
  • Manage internal and external research collaborations in areas related to translational science.
  • Contribute to IND and NDA submissions
  • Represent the company as a senior translational/medical statistician before appropriate scientific, medical, regulatory, business and other professional meetings.

  • What You Will Bring:

  • Your whole self.
  • MS or PhD in Statistics, Biostatistics, Mathematics or Informatics
  • Minimum 5 years of experience in drug development, oncology drug development a plus.
  • Experience working with data management and programming.
  • In-depth knowledge of translational science or early drug discovery, ideally with expertise in cell therapy.
  • Experience working with FDA is a plus.
  • Proven communication, presentation and influencing skills.
  • Highly developed problem solving and risk management skills.
  • Ability to drive, manage, execute and deliver results for complex multi-functional projects.
  • Highly developed collaborative working skills.
  • Proven ability to learn, derive and apply innovative methodologies
  • Excellent verbal and written communication skills, allowing for an open and effective dialogue throughout the company and for representation of the company at external events.
  • Good understanding of nonlinear mixed effects (Bayesian) models, the Pharmacometrics literature, and PK/PD modeling in general. A Bayesian mindset is an advantage.
  • The level of this position will be based on the final candidate’s qualifications.  
  • The role will entail operating in a fast-paced, highly dynamic environment with key company work partnerships including both internal and external stakeholders




  • We are committed to hiring the best talent from diverse backgrounds. A diverse workforce engenders richness of thought, creativity and discovery. We invite individuals who embrace intellectual achievement to bring their unique personal and professional journeys and together we will build transformative cell therapies for cancer patients.

    We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

    To all recruitment agencies: ArsenalBio does not accept agency resumes. Please do not forward resumes to our jobs alias, or Arsenalbio employees. ArsenalBio is not responsible for any fees related to unsolicited resumes.

    Apply     

    ArsenalBio was formed by its investors and scientific founders to discover, develop and commercialize curative and safe cellular therapies for patients with life threatening diseases, initially cancer.

    We believe the most productive and secure route to achieving this goal is to build scaled platforms of technologies challenged with scientific questions to yield informative data from hypothesis driven, well controlled experiments. These data will inform the design of ambitious, best-in-class, lead compositions. Our leads will be rigorously evaluated and honed until we are convinced our matured leads, called development candidates, can be prepared for testing in needy, and vulnerable patients.

    Our products will be designed to speed the transition of cell therapy from hospital-based to outpatient treatments, increasing access to more patients at lower cost to patients, health systems, and insurers.

    To achieve this mission, we are building diverse teams of talented, curious, and caring individuals who believe in our mission and our vision to be sustainable in our business plan, our work habits, and our personal lives.

    Our values create: a foundation for mutual respect, an engaging harmony from many voices, and unselfish behavior to aid our colleagues.

    This is ArsenalBio.
    This is our Company.


    Ken Drazan, MD
    Founding CEO

    Benefits

    Best in Class Health & Wellness Plans

    Flexible Office Hours

    Paid Parental Leave

    Healthy Kitchen Snacks

    Daily Catered Lunches

    Free Onsite Fitness Center

    Unlimited Vacation Days

    Generous compensation and equity packages

    Commuter Benefits

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