Discovery

Bold ideas. Reliable data. World-Class Science.

Designing therapies to cure our most important health challenges requires the audacity to advance a bold idea and explore new biologies with world-class science.

By pushing at the frontiers of science, challenging what we think we know, and holding ourselves to the highest standards of irrefutable proof, we are reshaping the future of curative cellular therapies.

Senior Research Associate, Synthetic Biology (2293-R-670-SBIO)

ArsenalBio’s mission is to develop efficacious and safe cellular therapies for patients with chronic diseases, initially cancer.  Our products are being designed to herald the transition of adoptive cell therapy from a hospital based treatment to outpatient therapy, like most other cancer treatments. 

Our people are our greatest asset, they bring scientific talents in molecular biology, immunology, pharmacology, protein chemistry, computational biology, automation, genome engineering, software and other fields to make the future happen now.


What You Will Do:

  • Design and execute experiments to develop and optimize synthetic immune receptors expressed on T cells for cell therapy applications.
  • Design and execute screens (pooled and arrayed) to identify improvements in ArsenalBio’s NextGen synthetic circuits for future portfolio products.
  • Functionally characterize integrated engineered T cells with various cellular assays (multicolor flow cytometry, cytotox (luciferase-based), Incucyte, Luminex).
  • Develop DNA constructs and libraries encoding immune receptor domains, variants and fusions from rational, semi-rational and randomized designs.
  • Work with interdisciplinary teams (Mol Bio, Comp Bio, NGS, Immunology) to design experiments, process data, and communicate results.
  • Use lab automation tools to execute workflows at high throughput to enable pooled/arrayed functional screening of DNA libraries in primary immune cells and cell lines.
  • Collect, analyze and interpret experimental data, keeping detailed accounts of experiments for group and company wide data presentations.
  • Maintain familiarity with the relevant cell therapy and synthetic biology literature. 

  • What You Will Bring:

  • B.A./B.S or M.S. in Bioengineering, Cell/Molecular Biology, Immunology, Protein Engineering, or a related discipline with 2+ years of combined relevant laboratory experience in industry and academia. 
  • Hands-on experience with aseptic cell culture technique. Experience performing T cell functional assays (T and tumor cell co-cultures, T cell cytotoxicity assays, etc.) is preferred. 
  • Familiarity with multicolor flow cytometry, molecular cloning (golden gate/gibson), and the use of semi-automated lab instruments (Viaflow, Dragonfly, or similar) is preferred. 
  • Experience performing data analysis and visualization with FlowJo, Prism, and R (dplyr, ggplot) or similar environments is preferred. 
  • Familiarity with the T cell immunology and CAR-T fields is a strong plus.
  • Ability to quickly learn new skills and knowledge on the job, demonstrate productivity, and deliver high-quality results.
  • Excellent organizational, written and verbal communication and interpersonal skills and demonstrated ability to perform as a team player.

  • ArsenalBio prioritizes the providing of a safe and healthy workplace that is consistent with COVID-19 public health guidance and legal requirements.  In order to protect our employees and visitors, we require all visitors (including candidates) and employees to present proof of being fully vaccinated against COVID-19 when coming onsite.

    We are committed to hiring the best talent from diverse backgrounds. A diverse workforce engenders richness of thought, creativity, and discovery. We invite individuals who embrace intellectual achievement to bring their unique personal and professional journeys and together we will build transformative cell therapies for cancer patients.

    We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

    To all recruitment agencies: ArsenalBio does not accept agency resumes. Please do not forward resumes to our jobs alias, or ArsenalBio employees. ArsenalBio is not responsible for any fees related to unsolicited resumes.

    Apply     

    ArsenalBio was formed by its investors and scientific founders to discover, develop and commercialize curative and safe cellular therapies for patients with life threatening diseases, initially cancer.

    We believe the most productive and secure route to achieving this goal is to build scaled platforms of technologies challenged with scientific questions to yield informative data from hypothesis driven, well controlled experiments. These data will inform the design of ambitious, best-in-class, lead compositions. Our leads will be rigorously evaluated and honed until we are convinced our matured leads, called development candidates, can be prepared for testing in needy, and vulnerable patients.

    Our products will be designed to speed the transition of cell therapy from hospital-based to outpatient treatments, increasing access to more patients at lower cost to patients, health systems, and insurers.

    To achieve this mission, we are building diverse teams of talented, curious, and caring individuals who believe in our mission and our vision to be sustainable in our business plan, our work habits, and our personal lives.

    Our values create: a foundation for mutual respect, an engaging harmony from many voices, and unselfish behavior to aid our colleagues.

    This is ArsenalBio.
    This is our Company.


    Ken Drazan, MD
    Founding CEO

    Benefits

    Best in Class Health & Wellness Plans

    Flexible Office Hours

    Paid Parental Leave

    Healthy Kitchen Snacks

    Daily Catered Lunches

    Free Onsite Fitness Center

    Unlimited Vacation Days

    Generous compensation and equity packages

    Commuter Benefits

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