Discovery

Bold ideas. Reliable data. World-Class Science.

Designing therapies to cure our most important health challenges requires the audacity to advance a bold idea and explore new biologies with world-class science.

By pushing at the frontiers of science, challenging what we think we know, and holding ourselves to the highest standards of irrefutable proof, we are reshaping the future of curative cellular therapies.

Scientist, CAR T Cell/Synthetic Biology (2240-N-670-SBIO)

ArsenalBio’s mission is to develop efficacious and safe cellular therapies for patients with chronic diseases, initially cancer.  Our products are being designed to herald the transition of adoptive cell therapy from a hospital based treatment to outpatient therapy, like most other cancer treatments. 

Our people are our greatest asset, they bring scientific talents in molecular biology, immunology, pharmacology, protein chemistry, computational biology, automation, genome engineering, software and other fields to make the future happen now.

Our approach requires novel receptors and gene circuits to empower cell therapies to sense their environment and respond as needed to resolve disease states. This role in ArsenalBio’s Synthetic Biology group lies on the forefront of development and application of those novel synthetic receptors. In it, you will interface closely with colleagues across ArsenalBio’s Discovery, Technology and Medical Sciences departments, as well as external collaborators and thought leaders.

What You Will Do:

  • Lead the high-throughput and high-content screening of synthetic immune receptors for a portfolio of cell therapy applications
  • Develop and apply methods for pooled and arrayed high-throughput functional screening of large protein libraries in primary immune cells and cell lines
  • Develop DNA constructs and libraries encoding immune receptor domains, variants and fusions from rational, semi-rational and randomized designs
  • Dissect and model the biochemical and functional characteristics of select receptor designs
  • Work with interdisciplinary teams to establish and test novel cell therapy approaches
  • Provide expert support for biological readouts of synthetic receptors across our broader scientific team
  • Maintain familiarity with the relevant current literature and its application to multiplexing readouts, synthetic immunology and cell therapy
  • Coordinate tasks across multiple projects, demonstrating prioritization and planning
  • Interpret and effectively execute experiments in line with project timelines and goals
  • Recruit and mentor junior scientists and research associates with relevant expertise

  • What You Will Bring:

  • PhD or equivalent in molecular biology, immunology, protein engineering or a related field; or Masters with 5+ years of relevant experience; or Bachelors with 7+ years of relevant experience
  • Experience with functional screening of engineered immune cells
  • Experience in developing flow cytometry protocols for synthetic biology applications
  • Collaborative experience with computational biologists and/or software engineers to help develop and use novel tools for construct design, experimental planning and/or data analysis
  • Entrepreneurial behaviors demonstrated by agility, accountability, transparency, resourcefulness, and ability to get things done
  • Demonstrated ability to perform as a team player

  • What You Might Bring:

  • Experience with high-throughput functional characterization of DNA and protein libraries in pooled and/or arrayed formats
  • Familiarity with R or similar environments for pipelining of routine data analysis
  • Working knowledge of NGS technologies and workflows
  • Experience with multiplexing/barcoding approaches for scaling experimental throughput

  • ArsenalBio prioritizes the providing of a safe and healthy workplace that is consistent with COVID-19 public health guidance and legal requirements.  In order to protect our employees and visitors, we require all visitors (including candidates) and employees to present proof of being fully vaccinated against COVID-19 when coming onsite.

    We are committed to hiring the best talent from diverse backgrounds. A diverse workforce engenders richness of thought, creativity, and discovery. We invite individuals who embrace intellectual achievement to bring their unique personal and professional journeys and together we will build transformative cell therapies for cancer patients.

    We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

    To all recruitment agencies: ArsenalBio does not accept agency resumes. Please do not forward resumes to our jobs alias, or ArsenalBio employees. ArsenalBio is not responsible for any fees related to unsolicited resumes.

    Apply     

    ArsenalBio was formed by its investors and scientific founders to discover, develop and commercialize curative and safe cellular therapies for patients with life threatening diseases, initially cancer.

    We believe the most productive and secure route to achieving this goal is to build scaled platforms of technologies challenged with scientific questions to yield informative data from hypothesis driven, well controlled experiments. These data will inform the design of ambitious, best-in-class, lead compositions. Our leads will be rigorously evaluated and honed until we are convinced our matured leads, called development candidates, can be prepared for testing in needy, and vulnerable patients.

    Our products will be designed to speed the transition of cell therapy from hospital-based to outpatient treatments, increasing access to more patients at lower cost to patients, health systems, and insurers.

    To achieve this mission, we are building diverse teams of talented, curious, and caring individuals who believe in our mission and our vision to be sustainable in our business plan, our work habits, and our personal lives.

    Our values create: a foundation for mutual respect, an engaging harmony from many voices, and unselfish behavior to aid our colleagues.

    This is ArsenalBio.
    This is our Company.


    Ken Drazan, MD
    Founding CEO

    Benefits

    Best in Class Health & Wellness Plans

    Flexible Office Hours

    Paid Parental Leave

    Healthy Kitchen Snacks

    Daily Catered Lunches

    Free Onsite Fitness Center

    Unlimited Vacation Days

    Generous compensation and equity packages

    Commuter Benefits

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