Discovery

Bold ideas. Reliable data. World-Class Science.

Designing therapies to cure our most important health challenges requires the audacity to advance a bold idea and explore new biologies with world-class science.

By pushing at the frontiers of science, challenging what we think we know, and holding ourselves to the highest standards of irrefutable proof, we are reshaping the future of curative cellular therapies.

Director, In Vivo Translational Pharmacology (22018-R-675-PCP)

ArsenalBio’s mission is to develop efficacious and safe cellular therapies for patients with chronic diseases, initially cancer.  Our products are being designed to herald the transition of adoptive cell therapy from a hospital based treatment to outpatient therapy, like most other cancer treatments. 

Our people are our greatest asset, they bring scientific talents in molecular biology, immunology, pharmacology, protein chemistry, computational biology, automation, genome engineering, software and other fields to make the future happen now.

We are seeking a highly motivated individual to lead our translational science and in vivo pharmacology at ArsenalBio. Reporting to the Vice President of Pre-Clinical Pharmacology, substantial expertise in tumor xenograft and syngeneic mouse models, oncology, immunology and biomarker discovery, as well as translational research and regulatory filings, is highly desirable. The successful individual will oversee and lead the in vivo modeling group and work with discovery researchers to enable target discovery and next generation adoptive cell therapies. In addition, the successful candidate will support in vivo assays, including pharmacokinetic and pharmacodynamic assessments, necessary to support product development and regulatory filings for pivotal clinical studies. This role requires an individual with outstanding communication and leadership skills.

What You Will Do:

  • Lead a group of scientists responsible for pre-clinical in vivo pharmacology efforts that utilize humanized, syngeneic, transgenic and other in vivo tumor models to support discovery science as well as pharmacology efforts to advance projects as required
  • Responsible for the collection, analysis, and interpretation of experimental data
  • Oversee all training and supervision of dosing studies, blood and tissue sampling, and surgeries as required
  • Develop novel pre-clinical efficacy studies to support discovery biology and IND-enabling research activities
  • Support product development and regulatory filings for pivotal clinical studies
  • Manage internal resource allocation and external collaborations
  • Responsible for working with team members to draft protocols and then ensure proper authorization and compliance
  • Participate and present data during internal research meetings and interface with cross-functional groups
  • Participate in the training of in vivo pharmacology personnel as needed for proficiency in all aspects of tumor model studies
  • Follow laboratory safety guidelines and practices

  • What You Will Bring:

  • Ph.D. in cancer biology or related field with 10+ years of relevant industry experience
  • Strong background in tumor biology, immunology, and tumor models including humanized, syngeneic, PDX and human cell line-derived models
  • Extensive hands-on experience with all aspects of running tumor models
  • Experience with various tumor models to demonstrate mechanisms of action
  • Experience working with antibody therapeutics is highly desired
  • Experience managing a team of scientists and research associates in a biopharmaceutical setting
  • Demonstrated ability to work collaboratively in a cross-functional environment
  • Experience in vivarium operations, resource management, and budget planning is required
  • Must have excellent troubleshooting, organization, and planning skills, and the ability to work under a timeline in a fast-paced environment
  • Excellent written and oral communication skills

  • ArsenalBio prioritizes the providing of a safe and healthy workplace that is consistent with COVID-19 public health guidance and legal requirements.  In order to protect our employees and visitors, we require all visitors (including candidates) and employees to present proof of being fully vaccinated against COVID-19 when coming onsite.

    We are committed to hiring the best talent from diverse backgrounds. A diverse workforce engenders richness of thought, creativity, and discovery. We invite individuals who embrace intellectual achievement to bring their unique personal and professional journeys and together we will build transformative cell therapies for cancer patients.

    We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

    To all recruitment agencies: ArsenalBio does not accept agency resumes. Please do not forward resumes to our jobs alias, or ArsenalBio employees. ArsenalBio is not responsible for any fees related to unsolicited resumes.

    Apply     

    ArsenalBio was formed by its investors and scientific founders to discover, develop and commercialize curative and safe cellular therapies for patients with life threatening diseases, initially cancer.

    We believe the most productive and secure route to achieving this goal is to build scaled platforms of technologies challenged with scientific questions to yield informative data from hypothesis driven, well controlled experiments. These data will inform the design of ambitious, best-in-class, lead compositions. Our leads will be rigorously evaluated and honed until we are convinced our matured leads, called development candidates, can be prepared for testing in needy, and vulnerable patients.

    Our products will be designed to speed the transition of cell therapy from hospital-based to outpatient treatments, increasing access to more patients at lower cost to patients, health systems, and insurers.

    To achieve this mission, we are building diverse teams of talented, curious, and caring individuals who believe in our mission and our vision to be sustainable in our business plan, our work habits, and our personal lives.

    Our values create: a foundation for mutual respect, an engaging harmony from many voices, and unselfish behavior to aid our colleagues.

    This is ArsenalBio.
    This is our Company.


    Ken Drazan, MD
    Founding CEO

    Benefits

    Best in Class Health & Wellness Plans

    Flexible Office Hours

    Paid Parental Leave

    Healthy Kitchen Snacks

    Daily Catered Lunches

    Free Onsite Fitness Center

    Unlimited Vacation Days

    Generous compensation and equity packages

    Commuter Benefits

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